Antivirals With Adjunctive Corticosteroids Prevent Clinical Progression of Early Coronavirus 2019 Pneumonia: A Retrospective Cohort Study.
Identifieur interne : 001883 ( Main/Exploration ); précédent : 001882; suivant : 001884Antivirals With Adjunctive Corticosteroids Prevent Clinical Progression of Early Coronavirus 2019 Pneumonia: A Retrospective Cohort Study.
Auteurs : Say Tat Ooi [Singapour] ; Purnima Parthasarathy [Singapour] ; Yi Lin [Singapour] ; Valliammai D O Nallakaruppan [Singapour] ; Shereen Ng [Singapour] ; Teck Choon Tan [Singapour] ; Serena Low [Singapour] ; Terence Tang [Singapour]Source :
- Open forum infectious diseases [ 2328-8957 ] ; 2020.
Abstract
This is a retrospective cohort study of hospitalized adults with coronavirus disease 2019 (COVID-19). Fifty-seven patients received treatment alone, and 35 patients received treatment with adjunctive prednisolone. A combination of corticosteroids and antivirals was associated with lower risk of clinical progression and invasive mechanical ventilation or death in early COVID-19 pneumonia.
DOI: 10.1093/ofid/ofaa486
PubMed: 33235888
PubMed Central: PMC7665708
Affiliations:
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Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi" sort="Lin, Yi" uniqKey="Lin Y" first="Yi" last="Lin">Yi Lin</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Epidemiology Unit, Khoo Teck Puat Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Clinical Epidemiology Unit, Khoo Teck Puat Hospital</wicri:regionArea><wicri:noRegion>Khoo Teck Puat Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nallakaruppan, Valliammai D O" sort="Nallakaruppan, Valliammai D O" uniqKey="Nallakaruppan V" first="Valliammai D O" last="Nallakaruppan">Valliammai D O Nallakaruppan</name><affiliation wicri:level="1"><nlm:affiliation>Division of General Medicine, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Division of General Medicine, Department of General Medicine, Khoo Teck Puat 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Hospital</wicri:regionArea><wicri:noRegion>Khoo Teck Puat Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j">Open forum infectious diseases</title><idno type="ISSN">2328-8957</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This is a retrospective cohort study of hospitalized adults with coronavirus disease 2019 (COVID-19). Fifty-seven patients received treatment alone, and 35 patients received treatment with adjunctive prednisolone. A combination of corticosteroids and antivirals was associated with lower risk of clinical progression and invasive mechanical ventilation or death in early COVID-19 pneumonia.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33235888</PMID><DateRevised><Year>2021</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2328-8957</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Open forum infectious diseases</Title><ISOAbbreviation>Open Forum Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Antivirals With Adjunctive Corticosteroids Prevent Clinical Progression of Early Coronavirus 2019 Pneumonia: A Retrospective Cohort Study.</ArticleTitle><Pagination><MedlinePgn>ofaa486</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ofid/ofaa486</ELocationID><Abstract><AbstractText>This is a retrospective cohort study of hospitalized adults with coronavirus disease 2019 (COVID-19). Fifty-seven patients received treatment alone, and 35 patients received treatment with adjunctive prednisolone. A combination of corticosteroids and antivirals was associated with lower risk of clinical progression and invasive mechanical ventilation or death in early COVID-19 pneumonia.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ooi</LastName><ForeName>Say Tat</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parthasarathy</LastName><ForeName>Purnima</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Unit, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nallakaruppan</LastName><ForeName>Valliammai D/O</ForeName><Initials>VD</Initials><AffiliationInfo><Affiliation>Division of General Medicine, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Shereen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of General Medicine, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Teck Choon</ForeName><Initials>TC</Initials><AffiliationInfo><Affiliation>Division of Rheumatology, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Low</LastName><ForeName>Serena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Terence</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Open Forum Infect Dis</MedlineTA><NlmUniqueID>101637045</NlmUniqueID><ISSNLinking>2328-8957</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">corticosteroids</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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name="Singapour"><noRegion><name sortKey="Ooi, Say Tat" sort="Ooi, Say Tat" uniqKey="Ooi S" first="Say Tat" last="Ooi">Say Tat Ooi</name></noRegion><name sortKey="Lin, Yi" sort="Lin, Yi" uniqKey="Lin Y" first="Yi" last="Lin">Yi Lin</name><name sortKey="Low, Serena" sort="Low, Serena" uniqKey="Low S" first="Serena" last="Low">Serena Low</name><name sortKey="Nallakaruppan, Valliammai D O" sort="Nallakaruppan, Valliammai D O" uniqKey="Nallakaruppan V" first="Valliammai D O" last="Nallakaruppan">Valliammai D O Nallakaruppan</name><name sortKey="Ng, Shereen" sort="Ng, Shereen" uniqKey="Ng S" first="Shereen" last="Ng">Shereen Ng</name><name sortKey="Ooi, Say Tat" sort="Ooi, Say Tat" uniqKey="Ooi S" first="Say Tat" last="Ooi">Say Tat Ooi</name><name sortKey="Parthasarathy, Purnima" sort="Parthasarathy, Purnima" uniqKey="Parthasarathy P" first="Purnima" last="Parthasarathy">Purnima Parthasarathy</name><name sortKey="Tan, Teck Choon" sort="Tan, Teck Choon" uniqKey="Tan T" first="Teck Choon" last="Tan">Teck Choon Tan</name><name sortKey="Tang, Terence" sort="Tang, Terence" uniqKey="Tang T" first="Terence" last="Tang">Terence Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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